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Bupropion sr 150 mg and weight loss 6 months; n = 12; drop-out rate 13%; mean change in weight (mm) –6.6 ± 3.5 mg/kg/d) • Tolerability and safety: Efficacy safety in obese subjects (n = 12); mean decrease in body weight of 4.2 ± 3.1 kg over 6 months; drop-out rate = 28% (over 12 weeks) • Cost: Efficacy and safety in obese subjects; mean cost per day = $835/day (over 12 weeks) • Regulatory: Clinical trial registration pending (ClinicalTrials.gov Identifier NCT01495921 and NCT03046784); author: Martin Kliger, MD, PhD and David S. Katz, MD, MPH Study 2 – A Randomized, Double-Blind, 3-Group, Placebo-Controlled bupropion sr 150 mg weight loss Trial of Adjunctive Naltrexone for Obesity and Cognitive Impairment Study Population Eligibility criteria: Healthy adult, 18 to 65, with no history of cardiovascular disease or depression, any other disorders that could be treated by adjunctive naltrexone (n = 16) Intervention Adjunctive naltrexone was provided in a three-period crossover design for 6 months (n = 16); study drug titration was supervised by study staff. Main Outcome Measures Body weight and composition were measured at baseline and the end of each treatment period. Cognitive performance was used to measure change in cognitive function at each time point. Results After 3 months of naltrexone, overweight and obese patients were significantly less likely to meet the criterion for severe weight gain (P =.01), as assessed by the short-term body-fat percentage method. No significant differences were observed between treatment groups for body weight (P =.21; n 16) or body composition (P =.20; n 16) price of generic bupropion at study termination. Efficacy In this trial, weight loss and total cholesterol levels were significantly reduced postintervention in both the naltrexone group (P =.03) and the placebo group (P <.001). No meaningful differences were observed between the two treatment groups for fasting insulin levels at baseline. Safety No significant differences were observed between treatment groups for adverse events at any time point. Adjunctive naltrexone was safe from the standpoint of adverse events, and all patients stopped the study drug regimen voluntarily. In two patients, liver abnormalities were identified. Side Effects Adjunctive naltrexone was generally well tolerated and did not cause serious adverse events during or after study drug administration. Effectiveness Based on the two-period crossover design, naltrexone could achieve a mean effect size of –0.15 at 6 months in the obese group (adjusted for baseline weight) and –0.23 at 12 months in the overweight group (1.14 and 1.25, respectively). The mean weight loss achieved by treatment with naltrexone was 8.3 ± 2.6 kg in the overweight group and 5.1 ± 2.8 kg in the obese group (P =.04). No clinically significant differences in weight loss were observed between treatment groups. Cost In this trial, naltrexone was cost-effective in the obese group (cost per day = $835/day) and cost-effective in the overweight group (cost per day = $1794/day). Regulatory ClinicalTrials.gov Identifier NCT01495921; author: Martin Kliger, MD, PhD and David S. Katz, MD, MPH Study 3 – A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Sustained Release Naltrexone for Obesity Eligibility criteria: Healthy adult, 18 to 65, with no history of cardiovascular disease or depression, any other disorders that could be treated by sustained bupropion hcl sr 300 mg weight loss release naltrexone (n = 15) Adjunctive sustained release naltrexone was provided in a three-period crossover design for 6 months (n = 15); study drug titration was supervised by study staff. Body weight and composition were measured at baseline and the end of each study period. Cognitive performance was used to measure change in cognitive function at each time point. After 3 months drugstore dupe mac angel lipstick of sustained release naltrexone, overweight and obese patients were significantly less likely to meet the criterion for severe weight gain (P =.02; n 13) as assessed by the short-term body-fat percentage method. No significant differences were observed between treatment groups for body weight (P =)

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What is the price of bupropion ? My mom says the best price is $3 per pill. Who should I pick up at the pharmacy? My mum says the best price is $3 per pill. Who should I pick up at the pharmacy? What does the price do on a one year supply of my medication? How long will it last for the drugstore? When I took my pills at Wal-mart yesterday. I felt a little strange and uncomfortable. I felt like we were being watched and I had trouble concentrating on things. It seemed like my body was becoming different. I thought it would last maybe a few days but eventually I just felt it dissipate. don't see where am I supposed to buy it? thought the price was a little low. Is there medication, what I should be buying or something else? how hard is drugstore dupes for mac angel lipstick it for me to fill out the form? Thank you! It's your own fault. When you fill out your order, it's to help the system find and place people in a position to purchase the medications you think will be needed the most. If you want to shop around for more choices, you can purchase prescriptions in the pharmacies near you. I recommend trying to pick out the cheapest prices you can. If are unsure, ask the pharmacist for reference prices. Just because your current pharmacist has only prescribed you generic doses of your medication, it doesn't mean other people won't want to purchase it for you. Ask the generic prescription they gave you to get some idea of how much it is. Once you have the prescription, call pharmacy to set up an appointment so they can verify that received the prescription, and then call you once arrive to confirm the order has been filled and set up a prescription pick up. Thank you again for making this necessary information available to customers. How do I buy generic drugs and can I use the mail order pharmacy? I have been hearing a lot recently about the new generic drugs being made available by the mail order/drugstore combo. I don't see what the benefit is to me other than having another way to get my medications. How long does an order take to pick up? Typically, prescriptions are delivered within 48 hours. The delivery is bupropion doses for weight loss typically timed to the next business day. If you are requesting it as soon you receive your prescription, please remember to call before your first pickup. Please call the pharmacy you selected for delivery time. When you arrive, please ask to speak with a pharmacist. Please be sure to use the name that was in prescription and the phone number where you called your pharmacy. When arrive, be sure to give your name and home telephone number. We do our best to be as prompt possible with delivering the medication. If you have a physician's authorization that takes up to 3 months process, it is usually expedited and we will try to accommodate your pharmacy schedule and be here for you as soon possible. We will contact you with your prescription once we have it in hand, usually within days. How much is a package of oral generic drugs ? What happens to it after being sent (not sold at drugstores) ? Packages of all oral generic drugs are shipped in a special box. The package will contain drugs and the expiration date. Packages of same lot are sent in the same box. pharmacist will make sure that everything comes out in a timely manner to keep you from having return the package later if expiration date gets missed. the prescription is expired or was purchased outside the United States, pharmacy may retain the order with a "for bulk purchase" number. If you have any questions about the packaging, do not hesitate to contact one of our customer service specialists. I just took the first pill and I am having an allergic reaction to the pill??? In theory, you will never actually react to a pill in the way that you think because allergic reactions are not necessarily predictable. However, in recent years, some people have gotten allergic to a single component of the drug (which is why a pharmacist will not take pill if you have been allergic before to that component). If this happens to you, please report this us at 800-831-2330, one of our Customer Service Representatives will be glad to help you. I am on the verge of going off my birth control and I don't know what to do. Can I stop taking a pill? Yes, you should give the pill about 4 days to pass. You should go back to what you were taking immediately before going off the pill. However, you may be prescribed a patch which will come off and not have the estrogen in it. You may need to stop taking the patch for at least 4 days after going off the.

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Ethereum, Bitcoin, and Blockchains

Ethereum

It’s been a long time since the last post. We’ve since released more versions of Eufloria, I picked up a Digital Entrepreneur of the Year Award, and I’m currently working part-time on Eufloria RPG with Rudolf Kremers and Anthony Flack.

For the most part, however, my time is spent working in the world of distributed ledgers. One of our fans started me off on bitcoin over 3 years ago, and since then it’s become much more than a hobby or a job. Indeed, I believe technology such as Ethereum to be world changing. I’m working with a number of start-ups, including some from the games world.

If you want to know more, I regularly tweet from @alex_amsel.

In the mean time, you can follow Eufloria RPG’s progress on Pivotal.

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Tuna Technologies becomes Triple Award Winner for Eufloria HD at Big Chip Awards 2013

The strangest thing happened last Thursday. Eufloria HD had been nominated for both Gaming and Design in the Big Chip Awards. These UK are awards primarily aimed at digital agencies. Somehow, we came from completely left field to win not only both these categories but also the grand prize, beating off the BBC’s iPlayer Radio app in the process. We’re still a bit dumbstruck! Anyway, pic and press release follows.

Big Chip 2013 Grand Prix Award

Tuna Technologies beat off all-comers to win 3 awards at the prestigious Big Chips awards ceremony, including the best of the night Grand Prix Award, Best Use of Design and Best Use of Gaming.

BAFTA nominated Eufloria, an ambient real-time strategy game, picked up plaudits from the judges for the beauty of its visuals, the simplicity and depth of its game play and the praise heaped on it by gamers. Described as a very accomplished piece of design, it united the judges to declare it Big Chip Grand Prix winner 2013.

“To come here and successfully take on such renowned and successful digital agencies is a wonderful achievement. Eufloria’s success continues to surprise and amaze us, and shows the power of our commitment to originality and quality” said Alex Amsel, Managing Director of Tuna.

The Big Chips are far and away the biggest digital awards outside London and the longest running in the UK. They are run by and for the industry, not for profit – by trade association, Manchester Digital working with partners including Digital Union in the North East, Leeds Digital Festival, Creative Liverpool, Creative Sheffield, Liverpool Vision and the Manchester Digital Development Agency.

Official website: www.bigchipawards.com

Eufloria HD is part of a continuing collaboration with Rudolf Kremers (Omni Systems) and Alex May, and was Apple’s Best iPad Game of 2012 Runner-Up. It’s available on the Apple App store and Google Play store for £2.99/$4.99/€3.99.

Official website: www.eufloria-game.com
Press Pack: http://www.eufloria-game.com/files/Eufloria_HD_PressPack.zip

About Tuna
Tuna is an international award-nominated boutique indie game production company who specialise in developing projects for mobile, traditional gaming and on-line platforms. With many years experience in the field, Tuna have worked with a range of partners including marketing and advertising agencies, independent game developers, universities, and solo artists. Services include digital consultancy, concept development, production management, software development and establishing software development partnerships. Brands Tuna has worked with include Family Guy, Big Brother, Cadbury, Asteroids, Boulder Dash, and indie hits Alien Hominid and Eufloria on platforms as wide ranging as iPhone, iPad, Android, Facebook, Nintendo DS, Nintendo Wii, Microsoft Xbox 360 and Sony PS3.

Official Website: www.tunahq.com
Twitter: Alex_Amsel

About Omni Systems Ltd
Eufloria is published by Omni Systems Limited, Rudolf Kremer’s indie media production company. Omni has been set up as a new kind of independent games (and other media) company, offering an alternative to corporate restraints and rewarding developers in a way that traditional game development often does not allow. Additionally Omni produces and develops other media including screenplays, comics, PS3 Dynamic Themes and more, while also offering consultancy services ranging from interactive software development to consultancy on creating virtual spaces. Current projects of note are two new games: StarLit and Neopolis, a series of Sci-Fi dynamic themes for PlayStation 3 and a comic called Spire.

Official Website: www.omni-labs.com

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The Bitcoin Bundle

The Bitcoin Bundle: Top indie developers support Bitcoins

Pay What You Want in Bitcoins for hit indie games Eufloria HD, World of Goo, And Yet It Moves, and Spirits.

Thursday 16th May 2013: The Bitcoin Bundle launched today, allowing Bitcoin users to pay whatever they want for four multiple award nominated Indie Games and contribute to the EFF. Unlike other bundles, this is entirely based around Bitcoin, the much talked about on-line currency. Not only do users buy with Bitcoins, but the developers are paid in Bitcoins.

Support has come from 2D Boy (World of Goo), Omni Systems (Eufloria), Spaces of Play (Spirits), and Broken Rules (And Yet It Moves). The developers all wished to show support for the nascent currency, seeing it as a way for players and creators to become a step closer together.

The Bitcoin Bundle

Bitcoin uses peer-to-peer technology to operate as a currency with no central authority. It can be used to pay anyone, anywhere in the world, almost instantly, anonymously, and without paying bank or other significant charges.

We created this bundle to be special – it’s exclusively handled in Bitcoin. We didn’t just want to have it as a payment option, we wanted to promote the currency itself”, said Alex Amsel, director of The Bitcoin Bundle.

 Marek Plichta, from contributor Spaces of Play, says more creative businesses should be paying attention to Bitcoin. “Digital distribution removed the need for publishers as the middleman between customers and game developers. Bitcoin might be able to do the same thing for all kinds of creative businesses and help them thrive.”

The Bitcoin Bundle is available for 2 weeks, from now, Thursday 16th May, until 30th May 2013. The games are DRM free, available for PC, Mac and Linux, and are on Steam where available. 10% of all proceeds will be gifted to the Electronic Frontier Foundation (https://www.eff.org/).

Bitcoins may be purchased from various companies, including Blockchain.info (International; not UK), Coinbase (US), BitInstant (US), and BitBargain (UK). The Bitcoin Bundle uses industry leading technology from Coinbase to handle Bitcoin transactions.

For more information

Official website: http://www.thebitcoinbundle.com

Press pack: http://www.thebitcoinbundle.com/press/bb1presspack.zip

Twitter: bitcoinbundle

Facebook: http://www.facebook.com/thebitcoinbundle

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Buy Eufloria with Bitcoins

It seems Bitcoin has been getting some more publicity recently. I’m a bit of a fan so I suggested to Rudolf that we accept Bitcoins. We’re considering how to go about this in some form if other people think it a good idea.

In the mean time, if anyone does want to have the Eufloria HD beta on PC, Mac, or Linux (as was in the Humble Bundle) then send us a message through the contact page, let us know when, how much and from where you have gifted, and we’ll get a build to you. At the moment we (well, I!) have to do this manually so please bare with me. I’m not online 24 hours a day 😉

How much are we charging? PAY WHAT YOU WANT!

Seriously.

ANYTHING.

Bitcoin payments will most likely go to funding us being able to accept them officially in some form so, as the saying goes, please give generously.

EDIT: This offer has now finished

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